I’ve been troubleshooting PC’s since the late 80’s when you needed to use jumpers to get a card to use the right memory location. In assessing this situation I think there are two possibilities.
The first you have mentioned, perhaps there is something unique about the way you play that is different from the rest of us and causing the issue.
The second would be to focus on your hardware and also look at what other software you’re running.
Here is an example of the above second possibility. On my practice laptop I haven’t uninstalled a click to run version of Office 365 because I keep some of my music organization in spreadsheets. Even though I’ve disabled every update switch and registry setting I can find it still runs telemetry calls home and who knows what when I wake up the laptop. If I’m running my Jamstix swing drummer, VB3 II and IK Leslie it’s pop and crackle time unless I let it do its thing for few minutes. Yes, I’m going to get around to removing Office one of these days!
You should walk through Glitch Free, the excellent windows optimization and tuning bible by none other than our fearless leader, Brad Robinson.
The following is moot if you’re running your laptop offline only but here goes.
I have the windows 10 built in anti-virus running but I’ve excluded it from scanning any plugin or music program folders although when the above problem occurs I see it as one of the many windows components eating up cpu cycles.
Speaking of viruses, maybe you should scan the machine with some scanners like AdwCleaner, MalwareBytes and Emisisoft command line scanner.