I’ve been using Neural’s Cory Wong and Fortin Cali for a while and they are both good imo. NI’s free Guitar Rig 6 is also nice if you want a JCM type. Way better than their v3, v4, v5 that I paid for and never used… But that said, my tube amps into a reactive load box and into high quality IRs are still a cut above imo.
I do agree most guitarists are exceptionally picky, I know I am…so to each their own, but sharing ideas is always a good thing imo.
As far as rigging, my “before amp” part is a hybrid of Cantabile hosted VSTs and hardware stomps. Still messing with it, but leaning towards dual Y switches to toggle the Cantabile piece in and out of signal path. Of course it ultimately depends on what is needed for any given setlist.
For amp FX loop, I’ve ditched my rack gear in favor of Cantabile. And for cab sim and post FX use a second laptop and second Behringer UMC202HD for stereo IRs and FX.
For “kids in school” reasons I always end up with a bunch of laptops that weren’t optional to buy and not worth much to sell, so they get repurposed for this…with a constant upgrade path for a few years yet…which is why it makes sense for me to configure this way. Otherwise I’d use a high spec laptop and a single 4 I/O Behringer.
As for the Behringers, super low latency, sound decent enough for guitar, very stable, 1 meg unbalanced inputs, are good enough even for use in live vocal processing, can be had for under $75 each…
And if I need/want to travel light, just ditch the hardware amps and put a suitable sim in that slot…and I’m good to go. One thing is for certain, as good as amp sims are now days, Cantabile opens up all new possibilities with all the routing and automation.