Yeah. Absolutely. I have my audio apps (primarily REAPER and Cantabile) set to trigger bitsum highest performance mode and it automatically applies optimizations to Windows in realtime for best performance.
I find it also helps when the CPU maxes out to keep everything responsive.
I also have it set to kill a few rogue CPU hogging processes that are unrelated to audio if they start up during audio work.
I’ve been running it now for many years and have never seen any negatives with it.
It’s also very good at finding those rogue processes when they run. Once something in the background triggers unwanted CPU use, you can see it in the Process Lasso window and add it to the kill list.
If it is something important and is needed, you can assign it rules when to run and when not to run so you’re not making permanent changes to the Windows registry which could be harmful.