I think a lot of us face these problems to a greater or lesser degree.
I find that the Windows zoom built into Aero (win7 and upwards) works well.
The shortcuts are win key + +, win key + -, win key + escape.
Here’s a demo. At about 1m08s into the video it shows the full screen zoom that I prefer.
Additionally, because I use laptops or mini keyboards I map a button on the right of the keyboard to give me an extra win key. This allows me to zoom with only one hand (the span is just too great to hit the normal win key on the left and get to the + or -). I use Sharpkeys for the mapping.