IK Multimedia B3X GUI problem

I bit the bullet and purchased IK’s B3X. I’m having an issue when I open the program in C3. The audio crackles badly and completely clears up when I close the GUI. This problem does not happen as stand alone. I’m using Voicemeeter Banana, by the way.
C3 is v.3236.
Any ideas as to why this might happen?
UPDATE:
I forgot to mention, I also have Amplitube 4 in the rack,as well. The problem only occurs when a Leslie cab is loaded. No problem with a Marshall, Fender cab, etc.

Sounds like your video driver has a conflict. Is it up to date?

Thanks for the tip. I’ll check that out.