Same here…patches with relatively long release times, when playing more than one note at the same time, produce lots of audio glitches with my usual settings (44.1kHz, 512 sample buffer, no double buffering =>11.61 ms).
Checking “Double Buffered Audio” already makes things much better.
My system is a Ryzen 5 3400, as listed here:
https://community.cantabilesoftware.com/uploads/default/original/2X/9/915ccd355982855ae450bc5cc7766ca541c1b0e6.png
Gabriel
Edit: Here is a link to the complete thread where I found the table above