Hi Lee,
A couple of questions:
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Are you seeing load spikes at the time of loading UVI and afterwards? Wondering if this is a sample conversion/manipulation type problem, or related to excessive load and not keeping up.
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Does turning Cantabile’s multi-core support off and loading just UVI work?
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Does UVI have a multi-core option? (can’t remember off hand, but if see, see this)
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Does closing UVI while the distortion is happening and loading another instrument return to normal sound?
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What is the Page Fault (pf) reading doing during all this.
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Does it only occur immediately after loading the plugin or if you let it sit for a while do things return to normal.
(Sorry for all the questions… just trying to break down what this might be).